The IMPUCT 2 project, “Technological Development of Polymeric Implants for Sustained Drug Release”, is a project that aims to generate new knowledge and respond to a set of technical and scientific challenges, in order to develop a pharmaceutical product with potential for use in humans.

An active substance delivery technology, such as polymeric implants, which enables a constant release of the active substance over a prolonged period of time, has the potential to increase treatment efficacy by reducing fluctuation in the plasma profile of the drug, keeping it within the therapeutic range, with fewer side effects and enables a reduction in the number of injections throughout the treatment period, thus increasing patient compliance.

As such, the following objectives have been established:

- Investigate the optimal formulation of the prototype implant ideally for monthly use;

- Investigate operations and variables of the implant production process for robust and scalable manufacturing;

- Develop analytical methods that enable the biological activity of the active substance to be validated in vitro;

- Investigate the in vivo efficacy of the prototype, through study in animal models and characterisation of its pharmacokinetic properties.